We've had a run of patients with large neck glands (cervical lymphadenitis) in lately. The first, a 16 year-old who presented with a sore throat and dehydration, had obvious glandular fever. Her glands were so large, her chin had nearly disappeared into her neck. The tonsils were red with exudate, and her liver and spleen were enlarged. Her lymphocyte count was 26. She had a positive monospot (unsurprisingly).
Last night's crop of new patients included a 7 year-old with a left-sided painful neck swelling and an 8-month old with a non-tender 2cm neck lump. Both patients had had monospots sent, to which the consultant said "but monospots are rubbish anyway." So I thought I'd look up exactly how rubbish they are.
I found this on Medscape:
its sensitivity is only 20% in young children. This test is frequently used to assess EBV infection in older children (>5 years-old). It is easy to perform and has a sensitivity of 85% in older children and a specificity of 97% (Peter & Ray, 1998).
here's a more complete answer
ok now i'm bored.
